Middleton Place is a National Historic Landmark originally constructed as a plantation. It was home to several generations of the Middleton family, dating as far back to the 1740s. Once a pre-war rice plantation, the grounds now feature an elaborate garden showcasing a diverse array of floral varieties.

The lush grounds and the house itself now function as a museum, with tours ongoing throughout the year for both tourists and student field trips. The grounds are purportedly home of the oldest landscaped gardens in the United States.

The House Museum - the only remaining structure of this once grand, three-complex estate - portrays 18th-century life and style. The stableyards house a collection of livestock characteristic of the era. Keepers, smiths and artisans also populate the grounds to evoke a lively pre-war era atmosphere.

The grounds fall under the stewardship of the Middleton Place Foundation. The Middleton Place Restaurant serves traditional Southern cuisine, authentic to plantation era dining. The grounds also offers guest accommodations at the Inn at Middleton Place.